Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors

Bioorg Med Chem Lett. 2009 Feb 1;19(3):850-3. doi: 10.1016/j.bmcl.2008.12.003. Epub 2008 Dec 6.

Abstract

Matched molecular pair analysis has been used in design of inhibitors of glycogen phosphorylase.

MeSH terms

  • Carbon / chemistry
  • Carboxylic Acids / chemistry
  • Chemistry, Pharmaceutical / methods*
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Glycogen Phosphorylase / antagonists & inhibitors*
  • Glycogen Phosphorylase / chemistry
  • Inhibitory Concentration 50
  • Methylation
  • Models, Chemical
  • Multivariate Analysis
  • Nitrogen / chemistry
  • Quantitative Structure-Activity Relationship
  • Solubility
  • Tetrazoles / chemistry
  • Water / chemistry

Substances

  • Carboxylic Acids
  • Enzyme Inhibitors
  • Tetrazoles
  • Water
  • Carbon
  • Glycogen Phosphorylase
  • Nitrogen