Abstract
Effects of misoprostol on histologic and biochemical alterations caused by CCl4 were investigated in the rat. Misoprostol protected against CCl4-induced liver injury. A close correlation occurred between biochemical data and morphological changes. This hepatoprotective effect was observed only when misoprostol was given 30 min before CCl4.
MeSH terms
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Alprostadil / analogs & derivatives*
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Alprostadil / pharmacology
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Animals
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Aspartate Aminotransferases / blood
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Carbon Tetrachloride / toxicity*
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Chemical and Drug Induced Liver Injury
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Liver / drug effects*
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Liver / pathology
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Liver Diseases / pathology
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Liver Diseases / prevention & control*
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Male
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Misoprostol
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Rats
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Rats, Inbred Strains
Substances
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Misoprostol
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Carbon Tetrachloride
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Aspartate Aminotransferases
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Alprostadil