Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes

J Org Chem. 2009 Feb 6;74(3):1337-40. doi: 10.1021/jo802460z.

Abstract

The palladium-catalyzed hydrostannation of terminal arylalkynes was achieved. The regioselectivity of the H-Sn bond addition across the triple bond was found to be controlled by an ortho substituent on the aromatic ring, whatever its electronic nature, to give exclusively alpha-branched vinylstannanes 2 in accordance with Markovnikov's rule. Subsequent Stille cross-coupling reaction of 2 with a variety of aryl halides readily provided, in moderate to good yields, a family of functionalized 1,1-diarylethylenes 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Benzene Derivatives / chemical synthesis*
  • Benzene Derivatives / chemistry
  • Catalysis
  • Ethylenes / chemical synthesis*
  • Palladium / chemistry
  • Trialkyltin Compounds / chemistry*

Substances

  • Alkynes
  • Benzene Derivatives
  • Ethylenes
  • Trialkyltin Compounds
  • Palladium