The word metastasis came from grec "I move". Bayle and Récamier were the first to show the relation between a secondary tumor from a primitive carcinoma but it is really Stephen Paget who is the father of the "seed and soil" theory to explain metastasis dissemination. Since, a lot of works have been done to better understand the metastasis physiopathology and in particular Judah Folkman participated very actively in angiogenesis mechanisms research. Today, even if all is not totally understood, physicians know that metastasis is a decisive event in the carcinoma story.