Sulfur conjugates as putative pneumotoxic metabolites of the pyrrolizidine alkaloid, monocrotaline

Adv Exp Med Biol. 1991:283:605-12. doi: 10.1007/978-1-4684-5877-0_76.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biotransformation
  • Cysteine / analogs & derivatives
  • Cysteine / metabolism
  • Cysteine / toxicity
  • Glutathione / metabolism
  • Glutathione / toxicity
  • Liver / metabolism
  • Lung / drug effects*
  • Monocrotaline
  • Pyrrolizidine Alkaloids / metabolism
  • Pyrrolizidine Alkaloids / pharmacokinetics
  • Pyrrolizidine Alkaloids / toxicity*
  • Rats

Substances

  • Pyrrolizidine Alkaloids
  • 7-cysteinyldehydroretronecine
  • glutathione-dehydro-retronecine conjugate
  • Monocrotaline
  • Glutathione
  • Cysteine