The crystal structure of the mineral routhierite, Tl(Cu,Ag)(Hg,Zn)(2)(As,Sb)(2)S(6), was solved and refined for the first time by means of single-crystal X-ray diffraction. The crystal structure consists of (Cu,Ag)S(4) and (Hg,Zn)S(4) tetrahedra, which share corners to form a framework with channels parallel to [001]. These channels contain TlS(6) and (As,Sb)S(3) polyhedra that share corners and edges with the tetrahedra. The crystal-chemical relationships with other Tl-Hg sulfosalts are outlined. The structure determination reported in this study definitively confirms that routhierite and stalderite possess the same crystal structure.