Iron(III) chloride catalyzed oxidative coupling of aromatic nuclei

J Org Chem. 2009 Jan 16;74(2):935-8. doi: 10.1021/jo8021633.

Abstract

Easily available and nontoxic FeCl(3) catalyzes intramolecular oxidative coupling for the direct construction of the phenanthrene ring using meta-chloroperbenzoic acid as sole oxidant at room temperature in excellent yields. The mechanistic investigations show that FeCl(3)-catalyzed coupling proceeds through the heterolytic coupling (A(+) + B). The catalytic approach has been applied to intermolecular biaryl coupling of 2-naphthols and phenol ether.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Chlorides
  • Chlorobenzoates / chemistry
  • Ethers / chemistry
  • Ferric Compounds / chemistry*
  • Naphthols / chemistry
  • Oxidants / chemistry
  • Oxidation-Reduction
  • Phenol / chemistry

Substances

  • Chlorides
  • Chlorobenzoates
  • Ethers
  • Ferric Compounds
  • Naphthols
  • Oxidants
  • Phenol
  • 3-chloroperbenzoic acid
  • 2-naphthol
  • ferric chloride