The immune status has been studied at 44 patients with a chronic pancreatitis (CP). Control group consisting of healthy 36 persons. Infringements of the immune status are found out in patients CP and also a pressure humoral a component of immunity. Inclusion in the scheme of complex treatment patients of a CP immunomodulin (1.2-1.8 mg on a course of therapy) led to elimination of the expressed T-cellular immunodeficiency in its group and promoted restoration of some parameters humoral a component of immunity. Immunomodulin possessed medical and immunocorrection action at patients of a CP.