A TRP channel-steroid marriage

Nat Cell Biol. 2008 Dec;10(12):1383-4. doi: 10.1038/ncb1208-1383.

Abstract

A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / metabolism
  • Ion Channel Gating / drug effects
  • Mice
  • Pregnenolone / pharmacology
  • Rats
  • Receptors, Steroid / metabolism*
  • TRPM Cation Channels / metabolism*

Substances

  • Receptors, Steroid
  • TRPM Cation Channels
  • pregnenolone sulfate
  • Pregnenolone