Abstract
This article deals with the mechanisms by which local immune stimulation is transmitted to the periphery, leading to systemic inflammation. We concentrate on the role of three signalling molecules: interleukin-1, interleukin-6, and tumour necrosis factor alpha. These cytokines provide a direct link between local and systemic inflammation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acute-Phase Reaction
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Animals
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Cytokines / antagonists & inhibitors
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Cytokines / physiology*
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Humans
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Inflammation* / immunology
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Interleukin-1 / physiology
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Interleukin-6 / physiology
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Tumor Necrosis Factor-alpha / physiology
Substances
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Cytokines
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Interleukin-1
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Interleukin-6
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Tumor Necrosis Factor-alpha