Attenuation by a thousand cuts

N Engl J Med. 2008 Nov 20;359(21):2283-5. doi: 10.1056/NEJMcibr0805820.
No abstract available

MeSH terms

  • Capsid Proteins / genetics*
  • Codon
  • Cytopathogenic Effect, Viral
  • Genome, Viral*
  • Humans
  • Mutation
  • Poliovirus / genetics*
  • Poliovirus / pathogenicity
  • Poliovirus / physiology
  • RNA, Viral / ultrastructure
  • Vaccines, Attenuated*
  • Virulence
  • Virus Replication

Substances

  • Capsid Proteins
  • Codon
  • RNA, Viral
  • Vaccines, Attenuated