Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus

Lin Du; Tianjiao Zhu; Hongbing Liu; Yuchun Fang; Weiming Zhu; Qianqun Gu

doi:10.1021/np800303t

Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus

J Nat Prod. 2008 Nov;71(11):1837-42. doi: 10.1021/np800303t. Epub 2008 Nov 6.

Authors

Lin Du¹, Tianjiao Zhu, Hongbing Liu, Yuchun Fang, Weiming Zhu, Qianqun Gu

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

PMID: 18986198
DOI: 10.1021/np800303t

Abstract

Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Aspergillus / chemistry*
China
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Polyketides / chemistry
Polyketides / isolation & purification*
Polyketides / pharmacology*

Substances

Antineoplastic Agents
Polyketides