Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents

F F Abdel-Latif; E K Ahmed; R Mekheimer; M M Mashaly

doi:10.1007/BF02973949

Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents

Arch Pharm Res. 1997 Oct;20(5):507-9. doi: 10.1007/BF02973949.

Authors

F F Abdel-Latif¹, E K Ahmed, R Mekheimer, M M Mashaly

Affiliation

¹ Chemstry Department, Faculty of Science, El-Minia University, El-Minia, Egypt.

PMID: 18982499
DOI: 10.1007/BF02973949

Abstract

Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanism were reported and supported via a second synthetic route.