Patient with obstructive sleep apnea-hypopnea syndrome and SCN5A mutation (R1193Q polymorphism) associated with Brugada type 2 electrocardiographic pattern

J Electrocardiol. 2009 May-Jun;42(3):250-3. doi: 10.1016/j.jelectrocard.2008.08.042. Epub 2008 Oct 30.

Abstract

We describe a 45-year-old Asian man with Brugada-type 2 electrocardiogram and probable nocturnal agonal respiration. After genetic screening, drug challenge test and polysomnography examination, we ruled out Brugada syndrome and identified obstructive sleep apnea-hypopnea syndrome. Therefore, obstructive sleep apnea-hypopnea syndrome should be considered as a rare differential diagnosis for Brugada syndrome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brugada Syndrome / complications
  • Brugada Syndrome / diagnosis*
  • Brugada Syndrome / genetics*
  • Diagnosis, Differential
  • Electrocardiography / methods*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics
  • Polymorphism, Single Nucleotide / genetics*
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / diagnosis*
  • Sleep Apnea, Obstructive / genetics*