Targeting a TAF to make muscle

Mol Cell. 2008 Oct 24;32(2):164-6. doi: 10.1016/j.molcel.2008.10.004.

Abstract

In a recent issue of Molecular Cell, Deato et al. (2008) elucidate the basis by which the muscle-specific activator MyoD recruits the core transcription machinery to the promoter of a key regulatory gene involved in myogenic differentiation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Gene Expression Regulation / physiology
  • Homeodomain Proteins / metabolism*
  • Mice
  • Muscle Fibers, Skeletal / cytology
  • Muscle Fibers, Skeletal / metabolism*
  • MyoD Protein / physiology*
  • Myoblasts, Skeletal / cytology
  • Myoblasts, Skeletal / metabolism
  • Myogenin / genetics
  • Myogenin / metabolism
  • Promoter Regions, Genetic
  • TATA Box Binding Protein-Like Proteins / metabolism
  • TATA-Binding Protein Associated Factors
  • Transcription Initiation Site

Substances

  • Homeodomain Proteins
  • MyoD Protein
  • MyoD1 myogenic differentiation protein
  • Myog protein, mouse
  • Myogenin
  • TATA Box Binding Protein-Like Proteins
  • TATA-Binding Protein Associated Factors
  • TRF3 protein, mouse
  • Taf3 protein, mouse