Complete absolute configuration of integramide A, a natural, 16-mer peptide inhibitor of HIV-1 integrase, elucidated by total synthesis

Chembiochem. 2009 Jan 5;10(1):87-90. doi: 10.1002/cbic.200800443.

Authors

Marta De Zotti¹, Fernando Formaggio, Bernard Kaptein, Quirinus B Broxterman, Peter J Felock, Daria J Hazuda, Sheo B Singh, Hans Brückner, Claudio Toniolo

Affiliation

¹ Institute of Biomolecular Chemistry, CNR, Padova Unit, Department of Chemistry, University of Padova, Padua, Italy.

PMID: 18850604
DOI: 10.1002/cbic.200800443

No abstract available

MeSH terms

Amino Acid Sequence
Biological Products / chemical synthesis
Biological Products / chemistry*
Biological Products / pharmacology*
Chromatography, High Pressure Liquid
HIV Integrase / metabolism*
HIV Integrase Inhibitors / chemical synthesis
HIV Integrase Inhibitors / chemistry*
HIV Integrase Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Oligopeptides / chemical synthesis
Oligopeptides / chemistry*
Oligopeptides / pharmacology*
Stereoisomerism

Substances

Biological Products
HIV Integrase Inhibitors
Oligopeptides
integramide A
HIV Integrase
p31 integrase protein, Human immunodeficiency virus 1