Decline in pneumococcal meningitis in Spain after introduction of the heptavalent pneumococcal conjugate vaccine

Pediatr Infect Dis J. 2008 Nov;27(11):1020-2. doi: 10.1097/INF.0b013e31817bd2dc.

Abstract

All patients < or =14 years old with a diagnosis of pneumococcal meningitis (n = 160) were included (2001, 2004-2006). Incidence per 100,000 child <5 years old varied from 6.14 in 2001 to 2.83 in 2006 (54% of reduction, P < 0.01). There was a significant correlation (R2 = 0.9506) with PCV7 distribution increase. No significant changes in the incidence by nonvaccine serotypes were found when comparing 2001 and 2006. The case fatality rate was 7.5%.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Meningitis, Pneumococcal / epidemiology*
  • Meningitis, Pneumococcal / immunology
  • Meningitis, Pneumococcal / microbiology
  • Meningitis, Pneumococcal / prevention & control
  • Meningococcal Vaccines / administration & dosage*
  • Pneumococcal Vaccines / administration & dosage*
  • Polymerase Chain Reaction
  • Prospective Studies
  • Serotyping
  • Spain / epidemiology
  • Streptococcus pneumoniae / classification

Substances

  • Heptavalent Pneumococcal Conjugate Vaccine
  • Meningococcal Vaccines
  • Pneumococcal Vaccines