SSCP analysis of scnDNA for genetic profiling of Aedes aegypti

Am J Trop Med Hyg. 2008 Oct;79(4):511-7.

Abstract

We characterized genetic profiling markers for Aedes aegypti using single-strand conformation polymorphism (SSCP) analysis of single copy nuclear genes (scnDNA). Nucleotide variations at 18 loci were evaluated in 173 wild Ae. aegypti collected from a single population in northwestern Thailand. We identified seven scnDNAs with polymorphisms sufficient to determine a unique genetic profile for each mosquito examined. Six markers were derived from previously mapped cDNA loci. One marker was developed from a non-coding region of a gene. The number of alleles at each scnDNA locus ranged from 3 to 9. The described scnDNAs can be used to quickly fingerprint large numbers of Ae. aegypti to track the behavior of individual mosquitoes in the field.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aedes / genetics*
  • Aedes / physiology
  • Alleles
  • Animals
  • DNA / genetics*
  • Gene Dosage
  • Genetic Markers
  • Microsatellite Repeats
  • Oviposition
  • Polymorphism, Single-Stranded Conformational*

Substances

  • Genetic Markers
  • DNA