Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog

Cytokine. 1991 Jan;3(1):1-4. doi: 10.1016/1043-4666(91)90002-u.

Abstract

To investigate the possible hemodynamic effects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the pulmonary artery balloon-occluded pressure at baseline level. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, but no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Dogs
  • Heart Rate / drug effects
  • Hematocrit
  • Hemodynamics / drug effects*
  • Hemoglobins / metabolism
  • Interleukin-6 / blood
  • Interleukin-6 / pharmacology*
  • Oxygen / blood
  • Recombinant Proteins / blood
  • Recombinant Proteins / pharmacology
  • Stroke Volume / drug effects
  • Vascular Resistance / drug effects

Substances

  • Hemoglobins
  • Interleukin-6
  • Recombinant Proteins
  • Oxygen