Abstract
Retapamulin MICs of > or =2 microg/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Diterpenes / pharmacology
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Drug Resistance, Bacterial* / genetics
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pleuromutilins
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Polycyclic Compounds
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Sequence Analysis, DNA
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification
Substances
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ATP-Binding Cassette Transporters
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Anti-Bacterial Agents
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Bacterial Proteins
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Bridged Bicyclo Compounds, Heterocyclic
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Diterpenes
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Polycyclic Compounds
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VgA protein, Staphylococcus aureus
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retapamulin