Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

M Fusek; M Mares; J Vágner; Z Voburka; M Baudys

doi:10.1016/0014-5793(91)80040-a

Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

FEBS Lett. 1991 Aug 5;287(1-2):160-2. doi: 10.1016/0014-5793(91)80040-a.

Authors

M Fusek¹, M Mares, J Vágner, Z Voburka, M Baudys

Affiliation

¹ Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague.

PMID: 1879525
DOI: 10.1016/0014-5793(91)80040-a

Abstract

Two propart peptides of aspartic proteinases, the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

MeSH terms

Animals
Aspartic Acid Endopeptidases / antagonists & inhibitors*
Cathepsin D / antagonists & inhibitors
Cathepsin D / pharmacology*
Chickens
Enzyme Precursors / pharmacology*
Humans
Hydrogen-Ion Concentration
Pepsin A / antagonists & inhibitors
Pepsinogens / pharmacology*
Protease Inhibitors / pharmacology*

Substances

Enzyme Precursors
Pepsinogens
Protease Inhibitors
Aspartic Acid Endopeptidases
procathepsin D
Pepsin A
Cathepsin D