Abstract
Synthetic methodology of the caprazamycins, which are promising antibacterial nucleoside natural products, was developed. Palmitoylcaprazol, which possesses a simple fatty acyl side chain at the diazepanone moiety of caprazamycins, has been synthesized and exhibited antibacterial activity against pathogens threatening a public health. Simplification of the caprazamycins was further pursued to develop diketopiperazine analogs.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Azepines / chemical synthesis
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Azepines / chemistry
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Biological Factors / chemistry
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Biological Factors / pharmacology
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Structure-Activity Relationship
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Uridine / analogs & derivatives*
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Uridine / chemical synthesis
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Uridine / chemistry
Substances
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Anti-Bacterial Agents
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Azepines
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Biological Factors
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caprazol
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Uridine