Hemodynamic effects of a single moderate dose of alcohol in elderly subjects

J Stud Alcohol. 1991 Jul;52(4):377-9. doi: 10.15288/jsa.1991.52.377.

Abstract

The effects of 0.5 g ethanol/kg body weight and of an iso-volumic control drink were compared in eight normotensive subjects aged 70-96 years. Blood alcohol concentration reached a mean (+/- SEM) maximum of 44.4 +/- 5.0 mg/dl at 50 minutes after the start of drinking. Compared to control, alcohol increased mean sitting and standing heart rates by 3.4 +/- 1.3 (p = .08) and 5.4 +/- 1.9 (p less than .05) beats/minute, respectively; mean venous haematocrit rose by 3.9 +/- 1.3% (p less than .05). There were no significant changes in sitting or standing systolic or diastolic blood pressures after alcohol compared to the control drink. A single moderate dose of alcohol has only minor haemodynamic effects in normotensive elderly subjects. The rise in heart rate after alcohol may be a reflex response that helps to maintain blood pressure in the face of reduced circulating plasma volume due to alcohol-induced diuresis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / adverse effects
  • Alcohol Drinking / physiopathology*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Blood Volume / drug effects
  • Blood Volume / physiology
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Hematocrit
  • Hemodynamics / drug effects*
  • Hemodynamics / physiology
  • Humans
  • Male