Evaluation of microbial metabolites for trypanocidal activity: significance of biochemical and biological parameters in the mouse model of trypanosomiasis

Jpn J Med Sci Biol. 1991 Feb;44(1):7-16. doi: 10.7883/yoken1952.44.7.

Abstract

Trypanosomiasis is a parasitic disease, prevailing in both humans and animals, caused by a single-cell parasite, Trypanosoma spp. Three microbial metabolites, namely antiamoebin, F-857 and 6-MFA, were evaluated for trypanocidal activity by using a mouse model of trypanosomiasis, which is caused by T. evansi. The significance of the biological and biochemical parameters with respect to physio-pathology of trypanosomiasis and their implications in the evaluation of new trypanocidal compounds were discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents* / therapeutic use*
  • Blood Glucose / analysis
  • Disease Models, Animal
  • Fungal Proteins / therapeutic use*
  • Mice
  • Peptaibols
  • Peptides*
  • Peptides, Cyclic / therapeutic use
  • Trypanocidal Agents / therapeutic use*
  • Trypanosomiasis / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Blood Glucose
  • Fungal Proteins
  • Peptaibols
  • Peptides
  • Peptides, Cyclic
  • Trypanocidal Agents
  • antiamoebin
  • MFA 6 extract, Aspergillus ochraceus