3-(5-Alkyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generation

J Med Chem. 1991 Aug;34(8):2647-9. doi: 10.1021/jm00112a046.
No abstract available

MeSH terms

  • Acrylates / chemical synthesis
  • Acrylates / pharmacology*
  • Acrylates / therapeutic use
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Experimental / drug therapy
  • Chemical Phenomena
  • Chemistry
  • Half-Life
  • Humans
  • Interleukin-1 / antagonists & inhibitors*
  • Interleukin-1 / biosynthesis
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Molecular Structure
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Naphthols / chemical synthesis
  • Naphthols / pharmacology*
  • Naphthols / therapeutic use
  • Rats

Substances

  • Acrylates
  • Anti-Inflammatory Agents, Non-Steroidal
  • Interleukin-1
  • Naphthols
  • DA-E 5090