Liver injury due to 3-amino-1-methyl-5h-pyrido [4,3-b] indole (Trp-P-2) and its prevention by miso

Biosci Biotechnol Biochem. 2008 Aug;72(8):2236-8. doi: 10.1271/bbb.80253. Epub 2008 Aug 7.

Abstract

Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Carbolines / toxicity*
  • Liver / injuries*
  • Liver Diseases / prevention & control*
  • Male
  • Mice
  • Organ Size / drug effects
  • Soy Foods*

Substances

  • Carbolines
  • 3-amino-1-methyl-5H-pyrido(4,3-b)indole