Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes

C A Truman; J M Ford; C J Roberts

doi:10.1016/0006-2952(91)90061-9

Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes

Biochem Pharmacol. 1991 Jul 25;42(4):956-9. doi: 10.1016/0006-2952(91)90061-9.

Authors

C A Truman¹, J M Ford, C J Roberts

Affiliation

¹ Department of Medicine, Bristol Royal Infirmary, U.K.

PMID: 1867652
DOI: 10.1016/0006-2952(91)90061-9

Abstract

There may be as many as five metabolites of THA in man, four corresponding to products in the rat. The study provides some evidence that one of major metabolites is 1-hydroxy-THA but lends no support to the putative oxidative deamination pathway.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / metabolism
Chromatography, High Pressure Liquid / methods
Humans
Male
Microsomes, Liver / metabolism*
Rats
Rats, Inbred Strains
Tacrine / analogs & derivatives
Tacrine / blood
Tacrine / metabolism*
Tacrine / urine

Substances

Cholinesterase Inhibitors
Tacrine
velnacrine