Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4499-502. doi: 10.1016/j.bmcl.2008.07.052. Epub 2008 Jul 17.

Abstract

Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry / methods*
  • DNA / chemistry*
  • Deoxyribonucleases / chemical synthesis*
  • Deoxyribonucleases / chemistry*
  • Distamycins / pharmacology
  • Drug Design
  • Glycerol / chemistry
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Hydroxylamines / chemistry*
  • Kinetics
  • Metals / chemistry*
  • Nucleic Acid Conformation
  • Nucleic Acids / chemistry
  • Oximes / chemistry*
  • Solvents

Substances

  • Distamycins
  • Hydroxylamines
  • Metals
  • Nucleic Acids
  • Oximes
  • Solvents
  • stallimycin
  • DNA
  • Deoxyribonucleases
  • Glycerol