"What are you doing today? I'm suffering." So expressed himself Alphonse Daudet the French writer. The pain he had gave him the spirit when he wrote a text entitled "La Doulou" a word from the South of France meaning "The pain". Speaking about pain requires listening to suffering patients. Many of them can be good observers and describe pain deeply and subtly. This paper covers the clinical approach of pain in MS patients. Can pain be the first sign of MS, are they frequent, what are their specific properties, how do we classify them, how do we recognize them to alleviate the burden of pain. These are the daily questions we ask as neurologists, while running neurological examination and listening to each patient. Gathered information will hopefully help you to find an appropriate answer for each patient.