Abstract
The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X(L) and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / pharmacology*
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Apoptosis / drug effects
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Apoptosis Regulatory Proteins / genetics
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Apoptosis Regulatory Proteins / metabolism
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Leishmania infantum / cytology
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Leishmania infantum / drug effects*
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Leishmania infantum / genetics
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Leishmania infantum / metabolism
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Membrane Potential, Mitochondrial / drug effects
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Phospholipid Ethers / pharmacology*
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Phosphorylcholine / analogs & derivatives
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Phosphorylcholine / pharmacology
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Transfection
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bcl-X Protein / genetics
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bcl-X Protein / metabolism
Substances
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Antiprotozoal Agents
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Apoptosis Regulatory Proteins
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Phospholipid Ethers
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Recombinant Proteins
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bcl-X Protein
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Phosphorylcholine
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edelfosine
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miltefosine