Microtubule stabilization: formins assert their independence

Aaron D DeWard; Arthur S Alberts

doi:10.1016/j.cub.2008.06.001

Microtubule stabilization: formins assert their independence

Curr Biol. 2008 Jul 22;18(14):R605-8. doi: 10.1016/j.cub.2008.06.001.

Authors

Aaron D DeWard¹, Arthur S Alberts

Affiliation

¹ Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, 333 Bostwick Ave., N.E., Grand Rapids, Michigan 49503, USA.

PMID: 18644336
DOI: 10.1016/j.cub.2008.06.001

Abstract

Mammalian Diaphanous-related (mDia) formins are well known for their actin nucleation and filament elongation activities. They have since emerged as microtubule-binding proteins, and a recent study shows that mDia2 stabilizes microtubules independently of its actin nucleation activity.

MeSH terms

Actins / chemistry
Actins / metabolism
Animals
Carrier Proteins / chemistry
Carrier Proteins / metabolism*
Humans
Microtubule-Associated Proteins / chemistry
Microtubule-Associated Proteins / metabolism*
Microtubules / metabolism*
Models, Biological
Protein Binding

Substances

Actins
Carrier Proteins
Microtubule-Associated Proteins