The "bottom-up" model of evidence-based practice (EBP) emphasizes the principles of integrating best research evidence with clinical expertise and patient values. It is derived from multidisciplinary sources, including clinical medicine, epidemiology, and adult learning theory, and has been applied to many medical disciplines, including radiology. Central to its implementation in everyday busy radiology practice is its emphasis on accurate, rapid modern informatics/internet to get the best current research evidence into everyday practice. In this article, the authors apply the principles of EBP to the topic of cardiac computed tomography. EBP is ideally suited to asking, searching, appraising, applying, and evaluating the literature on this rapidly developing technology.