Abstract
In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacillus anthracis / enzymology*
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Bacillus anthracis / genetics
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Bacillus anthracis / growth & development*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Base Sequence
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Gene Expression Regulation, Bacterial
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Molecular Sequence Data
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Mutation
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Operon
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Promoter Regions, Genetic
Substances
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Bacterial Proteins
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Phosphotransferases (Alcohol Group Acceptor)
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pantothenate kinase