Hydrocephalus as a possible additional contributor to cognitive outcome in survivors of pediatric medulloblastoma

Psychooncology. 2008 Nov;17(11):1157-61. doi: 10.1002/pon.1349.

Abstract

Objectives: The purpose of the study was to assess the relationship between shunted hydrocephalus and intellectual, memory and academic functioning in a group of survivors of pediatric medulloblastoma.

Methods: Data from measures of cognitive, memory, academic and visual-motor functioning were gathered retrospectively from 35 survivors. Of these survivors, 10 (28.6%) required ventriculoperitoneal-shunt placement for hydrocephalus posttumor resection.

Results: Results revealed that participants with shunted hydrocephalus demonstrated significantly lower IQs, lower nonverbal intellectual functioning, lower academic skills in writing and math, and impairments in visual-motor abilities when compared with those without shunt.

Conclusions: These results highlight the need to explore other variables--in addition to radiation and chemotherapy--as risk factors for neurocognitive impairments in survivors. Furthermore, identification of physiological substrates underlying these deficits is needed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achievement
  • Adolescent
  • Cerebellar Neoplasms / complications*
  • Cerebellar Neoplasms / psychology
  • Cerebellar Neoplasms / therapy
  • Child
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Combined Modality Therapy
  • Female
  • Humans
  • Hydrocephalus / complications*
  • Hydrocephalus / psychology
  • Hydrocephalus / therapy
  • Intelligence
  • Learning Disabilities / diagnosis*
  • Learning Disabilities / psychology
  • Male
  • Mathematics
  • Medulloblastoma / complications*
  • Medulloblastoma / psychology
  • Medulloblastoma / therapy
  • Mental Recall
  • Neuropsychological Tests*
  • Psychomotor Performance
  • Retrospective Studies
  • Risk Factors
  • Survivors / psychology*
  • Ventriculoperitoneal Shunt / psychology
  • Wechsler Scales
  • Writing