Motor neuron disease: The curious ways of ALS

Nature. 2008 Jul 17;454(7202):284-5. doi: 10.1038/454284a.

Abstract

That mutations in the SOD1 enzyme underlie familial form of the motor neuron disease ALS is clear. But there seems to be more than one answer to the question of what are the consequences of such mutations.

Publication types

  • News

MeSH terms

  • Amyotrophic Lateral Sclerosis / enzymology
  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Animals
  • Humans
  • Membrane Proteins / metabolism
  • Mice
  • Mitochondria / metabolism
  • Motor Neurons / pathology
  • Mutation
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism
  • Superoxide Dismutase-1

Substances

  • Membrane Proteins
  • SOD1 protein, human
  • Sod1 protein, mouse
  • Superoxide Dismutase
  • Superoxide Dismutase-1