Abstract
A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure-activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the conformation of largazole.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Computer Simulation
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Depsipeptides / chemical synthesis*
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Depsipeptides / chemistry
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Depsipeptides / pharmacology
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy / methods
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Mice
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Models, Molecular
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Molecular Structure
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Monte Carlo Method
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Solutions / chemistry
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
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Thiazoles / pharmacology
Substances
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Depsipeptides
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Solutions
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Thiazoles
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largazole