Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors

J Enzyme Inhib Med Chem. 2008 Dec;23(6):996-1001. doi: 10.1080/14756360701832706.
No abstract available

MeSH terms

  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / metabolism
  • Azepines / chemistry*
  • Benzene / chemistry*
  • Cell Line
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Peptides / metabolism*
  • Piperidines / chemistry*
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*
  • Structure-Activity Relationship

Substances

  • Amyloid beta-Peptides
  • Azepines
  • Peptides
  • Piperidines
  • Spiro Compounds
  • Benzene