Abstract
The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / immunology*
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Antigens, Viral / immunology
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Burkitt Lymphoma / immunology
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Burkitt Lymphoma / virology
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Capsid / immunology
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Carcinoma / immunology
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Carcinoma / virology
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Cytotoxicity Tests, Immunologic
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Herpesvirus 4, Human / immunology*
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Humans
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Immune Sera
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Infectious Mononucleosis / immunology
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Leukemia, Myeloid / immunology
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Leukemia, Myeloid / virology
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Nasopharyngeal Neoplasms / immunology
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Nasopharyngeal Neoplasms / virology
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Neoplasms / immunology*
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Neoplasms / virology*
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Neutralization Tests
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Viral Matrix Proteins / immunology*
Substances
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Antibodies, Viral
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Antigens, Viral
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EBV-associated membrane antigen, Epstein-Barr virus
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Epstein-Barr virus early antigen
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Immune Sera
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Viral Matrix Proteins