Few cases of empyema thoracis due to Candida species have been reported from the world and India. A 46-year-old male with esophageal carcinoma, who had taken radiotherapy, presented with fever and dyspnea. The chest X-ray showed findings suggestive of empyema. The diagnosis was confirmed by culturing Candida albicans from aspirated fluid and blood culture. The patient responded to antifungal treatment. High index of suspicion is required to diagnose such rare cases.