Abstract
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen Presentation / immunology*
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Antigen-Antibody Complex / immunology
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Antigen-Presenting Cells / cytology
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Antigen-Presenting Cells / immunology
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Cell Proliferation
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Dendritic Cells / cytology
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Dendritic Cells / immunology
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Hematopoietic System / cytology
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Hematopoietic System / immunology
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Hemocyanins / immunology
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Histocompatibility Antigens Class I / immunology*
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Humans
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Immunoglobulin G / immunology*
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Ligands
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Lysosomal Membrane Proteins / immunology
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Lysosomes / immunology
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Mice
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Monocytes / cytology
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Monocytes / immunology
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Mutation / genetics
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Protein Binding
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Protein Processing, Post-Translational
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Protein Transport
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Receptors, Fc / immunology*
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology
Substances
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Antigen-Antibody Complex
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Histocompatibility Antigens Class I
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Immunoglobulin G
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Lamp1 protein, mouse
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Ligands
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Lysosomal Membrane Proteins
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Receptors, Fc
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Hemocyanins
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keyhole-limpet hemocyanin
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Fc receptor, neonatal