Base behavior behind budding breasts: integrins and mammary stem cell activity

Cell Stem Cell. 2008 Jul 3;3(1):5-6. doi: 10.1016/j.stem.2008.06.006.

Abstract

In a recent Nature Cell Biology paper, Taddei et al. (2008) reveal that deletion of beta1 integrin from K5-expressing mammary epithelial basal cells specifically attenuates ductal stem cell activity, without dramatically altering the basal cell layer, or morphogenesis overall.

MeSH terms

  • Animals
  • Cell Differentiation
  • Female
  • Integrin beta1 / physiology
  • Integrins / physiology*
  • Keratin-15
  • Keratin-5 / physiology
  • Lactation
  • Mammary Glands, Animal / cytology*
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Animal / physiology*
  • Mice
  • Milk / metabolism
  • Stem Cells / cytology
  • Stem Cells / physiology*

Substances

  • Integrin beta1
  • Integrins
  • Keratin-15
  • Keratin-5
  • Krt15 protein, mouse