Fine tuning of hepcidin expression by positive and negative regulators

Cell Metab. 2008 Jul;8(1):1-3. doi: 10.1016/j.cmet.2008.06.009.

Abstract

Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory cytokines. Three recent publications now identify a novel hepcidin suppressor, the transmembrane serine protease TMPRSS6 (also known as matriptase-2), which is required to sense iron deficiency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anemia / etiology
  • Animals
  • Antimicrobial Cationic Peptides / biosynthesis
  • Antimicrobial Cationic Peptides / genetics*
  • Antimicrobial Cationic Peptides / physiology
  • Gene Expression Regulation
  • Hepcidins
  • Homeostasis
  • Humans
  • Iron / metabolism
  • Membrane Proteins / physiology*
  • Serine Endopeptidases / physiology*

Substances

  • Antimicrobial Cationic Peptides
  • HAMP protein, human
  • Hepcidins
  • Membrane Proteins
  • Iron
  • Serine Endopeptidases
  • matriptase 2