First detection of the OXA-40 carbapenemase in P. aeruginosa isolates, located on a plasmid also found in A. baumannii

E Sevillano; L Gallego; J M García-Lobo

doi:10.1016/j.patbio.2008.05.002

First detection of the OXA-40 carbapenemase in P. aeruginosa isolates, located on a plasmid also found in A. baumannii

Pathol Biol (Paris). 2009 Sep;57(6):493-5. doi: 10.1016/j.patbio.2008.05.002. Epub 2008 Jun 27.

Authors

E Sevillano¹, L Gallego, J M García-Lobo

Affiliation

¹ Departamento Inmunología, Facultad de Medicina y Odontología, Universidad del País Vasco, Aptdo. 699, 48080 Bilbao, Spain. elena.sevillano@ehu.es

PMID: 18585868
DOI: 10.1016/j.patbio.2008.05.002

Abstract

The aim of this work was to carry out the molecular investigation of the OXA-40 carbapenemase detected in two isolates of Pseudomonas aeruginosa resistant to imipenem. The sequence showed 100% of homology with the gene previously described in Acinetobacter baumannii. Hybridization experiments located the gene on a plasmid also found in the OXA-40 control strain of A. baumannii.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter baumannii / enzymology*
Acinetobacter baumannii / genetics*
Bacterial Proteins / genetics*
Carbapenems / pharmacology
DNA, Bacterial / genetics
Drug Resistance, Bacterial
Plasmids / genetics
Pseudomonas aeruginosa / enzymology*
Pseudomonas aeruginosa / genetics*
beta-Lactamases / genetics*

Substances

Bacterial Proteins
Carbapenems
DNA, Bacterial
beta-Lactamases
carbapenemase