Abstract
The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Carbapenems / pharmacology
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Conjugation, Genetic / drug effects
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Conjugation, Genetic / genetics*
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DNA Transposable Elements / genetics*
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Drug Resistance, Multiple, Bacterial / genetics*
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Fluoroquinolones / pharmacology
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Humans
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Molecular Sequence Data
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Plasmids / genetics*
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Sequence Analysis, DNA
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beta-Lactamases / genetics
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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DNA Transposable Elements
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Fluoroquinolones
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beta-Lactamases