Abstract
The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Chromatography, Liquid
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Heme / chemistry
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Heme / metabolism*
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Malaria / drug therapy*
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Malaria / metabolism
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Mass Spectrometry
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Mice
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
Substances
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Antimalarials
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DU1301
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Sesquiterpenes
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Heme