Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure

HyunJun Kang; Seung Ku Lee; Min-Ho Kim; HyeJeong Choi; Sook-Hwan Lee; KyuBum Kwack

doi:10.1016/j.fertnstert.2008.03.035

Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure

Fertil Steril. 2009 Apr;91(4 Suppl):1339-43. doi: 10.1016/j.fertnstert.2008.03.035. Epub 2008 Jun 13.

Authors

HyunJun Kang¹, Seung Ku Lee, Min-Ho Kim, HyeJeong Choi, Sook-Hwan Lee, KyuBum Kwack

Affiliation

¹ Medical Genomics Laboratory, Pochon CHA University, Gyeonggi-do, Korea.

PMID: 18555221
DOI: 10.1016/j.fertnstert.2008.03.035

Abstract

To identify genes that are associated with premature ovarian failure, a linkage disequilibrium-based genome-wide association study with dense single nucleotide polymorphisms as genetic markers was performed. The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Chromosomes, Human, Pair 5
Coenzyme A Ligases / genetics*
Female
Genetic Predisposition to Disease / genetics*
Haplotypes / genetics
Humans
Linkage Disequilibrium / genetics
Polymorphism, Single Nucleotide / genetics*
Primary Ovarian Insufficiency / genetics*

Substances

Coenzyme A Ligases
ACSL6 protein, human