Abstract
We investigated the effect of relaxin on extracellular matrix remodeling in cultured myometrial compared with leiomyoma smooth muscle cells. Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Collagen / metabolism
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Dose-Response Relationship, Drug
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Elastin / metabolism
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Extracellular Matrix / metabolism
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Female
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Humans
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Leiomyoma / metabolism*
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Leiomyoma / pathology
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Myocytes, Smooth Muscle / drug effects*
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Myocytes, Smooth Muscle / metabolism*
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Myocytes, Smooth Muscle / pathology
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Myometrium / metabolism*
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Myometrium / pathology
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Pancreatic Elastase / metabolism*
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Protease Inhibitors / metabolism*
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Relaxin / pharmacology*
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Tissue Inhibitor of Metalloproteinase-1 / metabolism
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Tissue Inhibitor of Metalloproteinase-2 / metabolism
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alpha 1-Antitrypsin / metabolism
Substances
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Protease Inhibitors
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Tissue Inhibitor of Metalloproteinase-1
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alpha 1-Antitrypsin
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Tissue Inhibitor of Metalloproteinase-2
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Relaxin
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Collagen
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Elastin
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Pancreatic Elastase