Images of the same physical dimensions on the retina can appear to represent different-sized objects. One reason for this is that the human visual system can take viewing distance into account when judging apparent size. Sequentially presented images can also prompt spatial coding interactions. Here we show, using a spatial coding phenomenon (the tilt aftereffect) in tandem with viewing distance cues, that the tuning of such interactions is not simply determined by the physical dimensions of retinal input. Rather, we find that they are contingent on apparent size. Our data therefore reveal that spatial coding interactions in human vision are modulated by processes involved in the determination of apparent size.