Constituents from Clausena excavata

Chem Pharm Bull (Tokyo). 2008 Jun;56(6):827-30. doi: 10.1248/cpb.56.827.

Abstract

Three new coumarins containing a C(10) terpenoid side chain, clauslactones R - T (1 - 3), together with 14 known coumarins (4 - 17) and 11 known carbazole alkaloids (18 - 28), were isolated from the leaves and stems of Clausena excavata. Their structures were established by detailed spectroscopic analyses. Furthermore, the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis, which was the first example among coumarins with a C(10) terpenoid side chain. Additionally, compounds 22 and 27 were found to show moderate topoisomerase II inhibitory effects at 50 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clausena / chemistry*
  • Coumarins / chemistry*
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Topoisomerase II Inhibitors
  • X-Ray Diffraction

Substances

  • Coumarins
  • Enzyme Inhibitors
  • Topoisomerase II Inhibitors