IgA nephropathy: markers of progression and clues to pathogenesis

Kidney Int. 2008 Jun;73(12):1338-40. doi: 10.1038/ki.2008.158.

Abstract

The unpredictable progression of IgA nephropathy hinders its treatment. The correlation of renal dysfunction with the immunophenotype of leukocytic infiltrates revealed interstitial CD20(+) cells and tubular NKG7(+)(GMP-17(+))/CD8(+) intraepithelial cells as predictive markers of progression in early-phase IgA nephropathy. This suggests that adaptive and innate immune responses mediate progression.

Publication types

  • Comment

MeSH terms

  • Antigens, CD20 / analysis
  • Biomarkers / analysis
  • CD8-Positive T-Lymphocytes / immunology
  • Disease Progression
  • Epithelium / immunology
  • Epithelium / pathology
  • Glomerulonephritis, IGA / diagnosis*
  • Glomerulonephritis, IGA / immunology*
  • Glomerulonephritis, IGA / pathology
  • Humans
  • Immunity, Innate
  • Kidney Tubules / immunology*
  • Kidney Tubules / pathology
  • Membrane Proteins / analysis
  • Prognosis

Substances

  • Antigens, CD20
  • Biomarkers
  • Membrane Proteins
  • NKG7 protein, human